Local heating induces vascular and metabolic adjustments as a result of increased muscle tissue perfusion and delivery of oxygen and regulatory substances to the heated area(s). In addition to these responses, which are dependent on elevated flow and supply of regulatory substances, oxygen and nutrients, increased local temperature can also induce intracellular responses directly.
One such molecular response to passive heating is increased heat shock proteins (HSPs). HSPs protect cells from damage during stress with the intention of maintaining/improving cell function; this has led to HSPs being classified as a “molecular chaperones”.
The purpose of this experiment is to understand how nutritional/pharmacological manipulations of HSPs during passive heating can alter the molecular pathways underlying vascular and metabolic adjustments and adaptation to thermal interventions.
Related Research Outputs
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Meet the Principal Investigator(s) for the project
Dr Oliver Gibson - Dr Oliver Gibson is a Senior Lecturer in Exercise Physiology and a member of staff in the Division of Sport, Health and Exercise Sciences, Department of Life Sciences and a member of the Centre for Physical Activity in Health and Disease.
Oliver is the MSc Sport, Health and Exercise Sciences programme lead and module leader for SP1616 Introduction to Human Anatomy and Physiology, SP2605 Physiology of Sport and Exercise, and SP5603 Sport Performance Science. He is a fellow of the Higher Education Academy and a member of The Physiological Society.
Oliver's primary research interests relate to Applied Human Physiology and in particular the impact of Heat Stress on Human Health, Performance, and Function. Please see the Research Tab, for further details. Publications can be viewed in the 'Selected Publications' tab and via Google Scholar.
Oliver provides peer-review for a number of international journals, and has presented at numerous of national and international conferences winning several young investigator awards. Throughout his career he has provided physiology consultancy to a number of high performance sports.
Related Research Group(s)
Physical Activity in Health and Disease - The centre conducts interdisciplinary research to improve human health and performance through regular physical activity and exercise, and by limiting sedentary behaviour.
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Project last modified 02/10/2023